2hhn: Difference between revisions

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[[Image:2hhn.jpg|left|200px]]
{{Seed}}
[[Image:2hhn.png|left|200px]]


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{{STRUCTURE_2hhn|  PDB=2hhn  |  SCENE=  }}  
{{STRUCTURE_2hhn|  PDB=2hhn  |  SCENE=  }}  


'''Cathepsin S in complex with non covalent arylaminoethyl amide.'''
===Cathepsin S in complex with non covalent arylaminoethyl amide.===




==Overview==
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The synthesis and structure-activity relationship of a series of arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of P3 and P2 groups to improve overall physicochemical properties resulted in significant improvements in oral bioavailability over early lead compounds. An X-ray structure of compound 37 bound to the active site of cathepsin S is also reported.
The line below this paragraph, {{ABSTRACT_PUBMED_16876402}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16876402}}


==About this Structure==
==About this Structure==
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[[Category: Noncovalent]]
[[Category: Noncovalent]]
[[Category: Protease]]
[[Category: Protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:18:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:35:59 2008''