2hjg: Difference between revisions

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[[Image:2hjg.gif|left|200px]]
{{Seed}}
[[Image:2hjg.png|left|200px]]


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{{STRUCTURE_2hjg|  PDB=2hjg  |  SCENE=  }}  
{{STRUCTURE_2hjg|  PDB=2hjg  |  SCENE=  }}  


'''The crystal structure of the B. subtilis YphC GTPase in complex with GDP'''
===The crystal structure of the B. subtilis YphC GTPase in complex with GDP===




==Overview==
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The structure of a Bacillus subtilis YphC/GDP complex shows that it contains two GTPase domains that pack against a central domain whose fold resembles that of an RNA binding KH-domain. Comparisons of this structure to that of a homologue in Thermotoga maritima reveals a dramatic rearrangement in the position of the N-terminal GTPase domain with a shift of up to 60 A and the formation of a totally different interface to the central domain. This rearrangement appears to be triggered by conformational changes of the switch II region in this domain in response to nucleotide binding. Modeling studies suggest that this motion represents transitions between the "on" and "off" states of the GTPase, the effect of which is to alternately expose and bury a positively charged face of the central domain that we suggest is involved in RNA recognition as part of the possible role of this enzyme in ribosome binding.
The line below this paragraph, {{ABSTRACT_PUBMED_16894162}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16894162}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
The essential GTPase YphC displays a major domain rearrangement associated with nucleotide binding., Muench SP, Xu L, Sedelnikova SE, Rice DW, Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12359-64. Epub 2006 Aug 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16894162 16894162]
The essential GTPase YphC displays a major domain rearrangement associated with nucleotide binding., Muench SP, Xu L, Sedelnikova SE, Rice DW, Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12359-64. Epub 2006 Aug 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16894162 16894162]
Cloning, purification and preliminary crystallographic analysis of the Bacillus subtilis GTPase YphC-GDP complex., Xu L, Muench SP, Roujeinikova A, Sedelnikova SE, Rice DW, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):435-7. Epub 2006 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16682769 16682769]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Xu, L.]]
[[Category: Xu, L.]]
[[Category: Gtpase enga kh-domain]]
[[Category: Gtpase enga kh-domain]]
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