2hk5: Difference between revisions

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[[Image:2hk5.jpg|left|200px]]
{{Seed}}
[[Image:2hk5.png|left|200px]]


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{{STRUCTURE_2hk5|  PDB=2hk5  |  SCENE=  }}  
{{STRUCTURE_2hk5|  PDB=2hk5  |  SCENE=  }}  


'''Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247'''
===Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247===




==Overview==
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This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).
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{{ABSTRACT_PUBMED_16997556}}


==About this Structure==
==About this Structure==
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[[Category: Src-family]]
[[Category: Src-family]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:23:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:56:50 2008''