2hla: Difference between revisions

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[[Image:2hla.gif|left|200px]]
[[Image:2hla.png|left|200px]]


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==Overview==
{{ABSTRACT_2594067}}
We have determined the structure of a second human histocompatibility glycoprotein, HLA-Aw68, by X-ray crystallography and refined it to a resolution of 2.6 A. Overall, the structure is extremely similar to that of HLA-A2 (refs 1, 2; and M.A.S. et al., manuscript in preparation), although the 11 amino-acid substitutions at polymorphic residues in the antigen-binding cleft alter the detailed shape and electrostatic charge of that site. A prominent negatively charged pocket within the cleft extends underneath the alpha-helix of the alpha 1-domain, providing a potential subsite for recognizing a positively charged side chain or peptide N terminus. Uninterpreted electron density, presumably representing an unknown 'antigen(s)', which seems to be different from that seen in the HLA-A2 structure, occupies the cleft and extends into the negatively charged pocket in HLA-Aw68. The structures of HLA-Aw68 and HLA-A2 demonstrate how polymorphism creates and alters subsites (pockets) positioned to bind peptide side chains, thereby suggesting the structural basis for allelic specificity in foreign antigen binding.


==About this Structure==
==About this Structure==
2HLA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2HLA with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLA OCA].  
2HLA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2HLA with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLA OCA].  
==Reference==
Specificity pockets for the side chains of peptide antigens in HLA-Aw68., Garrett TP, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC, Nature. 1989 Dec 7;342(6250):692-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2594067 2594067]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Major Histocompatibility Complex]]
[[Category: Major Histocompatibility Complex]]
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
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Revision as of 15:18, 26 June 2008

File:2hla.png

Template:STRUCTURE 2hla

SPECIFICITY POCKETS FOR THE SIDE CHAINS OF PEPTIDE ANTIGENS IN HLA-AW68


Template:ABSTRACT 2594067

About this Structure

2HLA is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 2HLA with [Major Histocompatibility Complex]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:18:58 2008

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