2hm1: Difference between revisions

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[[Image:2hm1.gif|left|200px]]
{{Seed}}
[[Image:2hm1.png|left|200px]]


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{{STRUCTURE_2hm1|  PDB=2hm1  |  SCENE=  }}  
{{STRUCTURE_2hm1|  PDB=2hm1  |  SCENE=  }}  


'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''
===Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)===




==Overview==
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We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.
The line below this paragraph, {{ABSTRACT_PUBMED_17049233}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17049233}}


==About this Structure==
==About this Structure==
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[[Category: Tomasselli, A G.]]
[[Category: Tomasselli, A G.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:26:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:20:43 2008''