2hn7: Difference between revisions

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[[Image:2hn7.gif|left|200px]]
{{Seed}}
[[Image:2hn7.png|left|200px]]


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{{STRUCTURE_2hn7|  PDB=2hn7  |  SCENE=  }}  
{{STRUCTURE_2hn7|  PDB=2hn7  |  SCENE=  }}  


'''HLA-A*1101 in complex with HBV peptide homologue'''
===HLA-A*1101 in complex with HBV peptide homologue===




==Overview==
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A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).
The line below this paragraph, {{ABSTRACT_PUBMED_17142892}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17142892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17142892}}


==Disease==
==Disease==
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[[Category: Mhc-i]]
[[Category: Mhc-i]]
[[Category: Peptide-mhc-complex]]
[[Category: Peptide-mhc-complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:28:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:29:07 2008''
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