2hnk: Difference between revisions

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[[Image:2hnk.jpg|left|200px]]
{{Seed}}
[[Image:2hnk.png|left|200px]]


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{{STRUCTURE_2hnk|  PDB=2hnk  |  SCENE=  }}  
{{STRUCTURE_2hnk|  PDB=2hnk  |  SCENE=  }}  


'''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''
===Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans===




==Overview==
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The S-adenosylmethionine (SAM)-dependent O-methyltransferase from Leptospira interrogans (LiOMT) expressed by gene LA0415 belongs to the Methyltransf_3 family (Pfam PF01596). In this family all of the five bacterial homologues with known function are reported as SAM-dependent O-methylstransferases involved in antibiotic production. The crystal structure of LiOMT in complex with S-adenosylhomocysteine reported here is the first bacterial protein structure in this family. The LiOMT structure shows a conserved SAM-binding region and a probable metal-dependent catalytic site. The molecules of LiOMT generate homodimers by N-terminal swapping, which assists the pre-organization of the substrate-binding site. Based on the sequence and structural analysis, it is implied by the catalytic and substrate-binding site that the substrate of LiOMT is a phenolic derivative, which probably has a large ring-shaped moiety.
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{{ABSTRACT_PUBMED_17561415}}


==About this Structure==
==About this Structure==
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[[Category: Modified rossman fold]]
[[Category: Modified rossman fold]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:29:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:56:21 2008''

Revision as of 13:56, 28 July 2008

File:2hnk.png

Template:STRUCTURE 2hnk

Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans

Template:ABSTRACT PUBMED 17561415

About this Structure

2HNK is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.

Reference

Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans., Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W, J Struct Biol. 2007 Sep;159(3):523-8. Epub 2007 Apr 30. PMID:17561415

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