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| [[Image:2hnp.jpg|left|200px]] | | {{Seed}} |
| | [[Image:2hnp.png|left|200px]] |
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| {{STRUCTURE_2hnp| PDB=2hnp | SCENE= }} | | {{STRUCTURE_2hnp| PDB=2hnp | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B'''
| | ===CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B=== |
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| ==Overview==
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| Protein tyrosine phosphatases (PTPs) constitute a family of receptor-like and cytoplasmic signal transducing enzymes that catalyze the dephosphorylation of phosphotyrosine residues and are characterized by homologous catalytic domains. The crystal structure of a representative member of this family, the 37-kilodalton form (residues 1 to 321) of PTP1B, has been determined at 2.8 A resolution. The enzyme consists of a single domain with the catalytic site located at the base of a shallow cleft. The phosphate recognition site is created from a loop that is located at the amino-terminus of an alpha helix. This site is formed from an 11-residue sequence motif that is diagnostic of PTPs and the dual specificity phosphatases, and that contains the catalytically essential cysteine and arginine residues. The position of the invariant cysteine residue within the phosphate binding site is consistent with its role as a nucleophile in the catalytic reaction. The structure of PTP1B should serve as a model for other members of the PTP family and as a framework for understanding the mechanism of tyrosine dephosphorylation.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8128219}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8128219 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8128219}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Flint, A J.]] | | [[Category: Flint, A J.]] |
| [[Category: Tonks, N K.]] | | [[Category: Tonks, N K.]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:38 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:37:00 2008'' |
