2hpd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2hpd.jpg|left|200px]]
{{Seed}}
[[Image:2hpd.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hpd|  PDB=2hpd  |  SCENE=  }}  
{{STRUCTURE_2hpd|  PDB=2hpd  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S'''
===CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S===




==Overview==
<!--
Cytochrome P450BM-3, a bacterial fatty acid monoxygenase, resembles the eukaryotic microsomal P450's and their flavoprotein reductase in primary structure and function. The three-dimensional structure of the hemoprotein domain of P450BM-3 was determined by x-ray diffraction and refined to an R factor of 16.9 percent at 2.0 angstrom resolution. The structure consists of an alph and a beta domain. The active site heme is accessible through a long hydrophobic channel formed primarily by the beta domain and the B' and F helices of the alpha domain. The two molecules in the asymmetric unit differ in conformation around the substrate binding pocket. Substantial differences between P450BM-3 and P450cam, the only other P450 structure available, are observed around the substrate binding pocket and the regions important for redox partner binding. A general mechanism for proton transfer in P450's is also proposed.
The line below this paragraph, {{ABSTRACT_PUBMED_8342039}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8342039 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8342039}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Peterson, J A.]]
[[Category: Peterson, J A.]]
[[Category: Ravichandran, K G.]]
[[Category: Ravichandran, K G.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:32:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:14:54 2008''

Revision as of 04:14, 29 July 2008

File:2hpd.png

Template:STRUCTURE 2hpd

CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S

Template:ABSTRACT PUBMED 8342039

About this Structure

2HPD is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's., Ravichandran KG, Boddupalli SS, Hasermann CA, Peterson JA, Deisenhofer J, Science. 1993 Aug 6;261(5122):731-6. PMID:8342039

Page seeded by OCA on Tue Jul 29 07:14:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2hpd&oldid=732337"