2hrt: Difference between revisions

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[[Image:2hrt.jpg|left|200px]]
{{Seed}}
[[Image:2hrt.png|left|200px]]


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{{STRUCTURE_2hrt|  PDB=2hrt  |  SCENE=  }}  
{{STRUCTURE_2hrt|  PDB=2hrt  |  SCENE=  }}  


'''Asymmetric structure of trimeric AcrB from Escherichia coli'''
===Asymmetric structure of trimeric AcrB from Escherichia coli===




==Overview==
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The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive force, it mediates the efflux of bile salts, detergents, organic solvents, and many structurally unrelated antibiotics. Here, we report a crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups that allow asymmetry of the monomers. This structure reveals three different monomer conformations representing consecutive states in a transport cycle. The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.
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{{ABSTRACT_PUBMED_16946072}}


==About this Structure==
==About this Structure==
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[[Category: Rnd]]
[[Category: Rnd]]
[[Category: Tolc]]
[[Category: Tolc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:51:12 2008''

Revision as of 01:51, 28 July 2008

File:2hrt.png

Template:STRUCTURE 2hrt

Asymmetric structure of trimeric AcrB from Escherichia coli

Template:ABSTRACT PUBMED 16946072

About this Structure

2HRT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism., Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM, Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072

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