2hsx: Difference between revisions

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[[Image:2hsx.jpg|left|200px]]
{{Seed}}
[[Image:2hsx.png|left|200px]]


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{{STRUCTURE_2hsx|  PDB=2hsx  |  SCENE=  }}  
{{STRUCTURE_2hsx|  PDB=2hsx  |  SCENE=  }}  


'''NMR Structure of the nonstructural protein 1 (nsp1) from the SARS coronavirus'''
===NMR Structure of the nonstructural protein 1 (nsp1) from the SARS coronavirus===




==Overview==
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The nonstructural protein 1 (nsp1) of the severe acute respiratory syndrome coronavirus has 179 residues and is the N-terminal cleavage product of the viral replicase polyprotein that mediates RNA replication and processing. The specific function of nsp1 is not known. Here we report the nuclear magnetic resonance structure of the nsp1 segment from residue 13 to 128, which represents a novel alpha/beta-fold formed by a mixed parallel/antiparallel six-stranded beta-barrel, an alpha-helix covering one opening of the barrel, and a 3(10)-helix alongside the barrel. We further characterized the full-length 179-residue protein and show that the polypeptide segments of residues 1 to 12 and 129 to 179 are flexibly disordered. The structure is analyzed in a search for possible correlations with the recently reported activity of nsp1 in the degradation of mRNA.
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{{ABSTRACT_PUBMED_17202208}}


==About this Structure==
==About this Structure==
2HSX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSX OCA].  
2HSX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSX OCA].  


==Reference==
==Reference==
Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus., Almeida MS, Johnson MA, Herrmann T, Geralt M, Wuthrich K, J Virol. 2007 Apr;81(7):3151-61. Epub 2007 Jan 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17202208 17202208]
Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus., Almeida MS, Johnson MA, Herrmann T, Geralt M, Wuthrich K, J Virol. 2007 Apr;81(7):3151-61. Epub 2007 Jan 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17202208 17202208]
NMR assignment of the SARS-CoV protein nsp1., Almeida MS, Johnson MA, Wuthrich K, J Biomol NMR. 2006;36 Suppl 1:46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16821128 16821128]
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virus]]
[[Category: Virus]]
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