2hw4: Difference between revisions

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[[Image:2hw4.gif|left|200px]]
{{Seed}}
[[Image:2hw4.png|left|200px]]


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{{STRUCTURE_2hw4|  PDB=2hw4  |  SCENE=  }}  
{{STRUCTURE_2hw4|  PDB=2hw4  |  SCENE=  }}  


'''Crystal structure of human phosphohistidine phosphatase'''
===Crystal structure of human phosphohistidine phosphatase===




==Overview==
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Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. The structure of phosphohistidine phosphatase (PHPT1), the first identified eukaryotic-protein histidine phosphatase, has been determined to a resolution of 1.9A using multiple-wavelength anomalous dispersion methods. This enzyme can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues. Histidine 53 is proposed to play a major role in histidine dephosphorylation based on these observations and previous mutational studies. Models of peptide binding are discussed to suggest possible mechanisms for substrate recognition.
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{{ABSTRACT_PUBMED_16990267}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:07:17 2008''

Revision as of 06:07, 29 July 2008

File:2hw4.png

Template:STRUCTURE 2hw4

Crystal structure of human phosphohistidine phosphatase

Template:ABSTRACT PUBMED 16990267

About this Structure

2HW4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

First structure of a eukaryotic phosphohistidine phosphatase., Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Hallberg BM, J Biol Chem. 2006 Nov 10;281(45):33830-4. Epub 2006 Sep 21. PMID:16990267

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