2hyi: Difference between revisions

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[[Image:2hyi.~~gif~~|left|200px]]

[[Image:2hyi.png|left|200px]]

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~~'''~~Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA~~'''~~

===Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA===

~~==Overview==~~

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~~In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs.~~ The ~~complex is organized around a stable core~~, ~~which serves as a binding platform for numerous factors that influence messenger RNA function. Here~~, ~~we present~~ the ~~crystal structure of a tetrameric exon junction core complex containing~~ the ~~DEAD-box adenosine triphosphatase~~ (~~ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic~~. ~~eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded~~. ~~The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state~~, ~~and activation of~~ the ~~ATPase probably requires only modest conformational changes in eIF4AIII motif I~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16931718}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16931718 is the PubMed ID number.

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==About this Structure==

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[[Category: Splicing]]

[[Category: Translation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 06~~:52:02 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:56:03 2008''

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-[[Image:2hyi.gif|left|200px]]
+{{Seed}}
+[[Image:2hyi.png|left|200px]]
 <!--
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 {{STRUCTURE_2hyi|  PDB=2hyi  |  SCENE=  }}
-'''Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA'''
+===Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA===
-==Overview==
+<!--
-In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.
+The line below this paragraph, {{ABSTRACT_PUBMED_16931718}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16931718 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16931718}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Splicing]]
 [[Category: Translation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:52:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:56:03 2008''