2q1b: Difference between revisions

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New page: left|200px<br /> <applet load="2q1b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q1b, resolution 1.70Å" /> '''Carbonic Anhydrase ...
 
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[[Image:2q1b.gif|left|200px]]<br />
[[Image:2q1b.jpg|left|200px]]<br /><applet load="2q1b" size="350" color="white" frame="true" align="right" spinBox="true"  
<applet load="2q1b" size="450" color="white" frame="true" align="right" spinBox="true"  
caption="2q1b, resolution 1.70&Aring;" />
caption="2q1b, resolution 1.70&Aring;" />
'''Carbonic Anhydrase II in Complex with Saccharin'''<br />
'''Carbonic Anhydrase II in Complex with Saccharin'''<br />
==Disease==
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]


==About this Structure==
==About this Structure==
2Q1B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, HG, BEZ and LSA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2Q1B OCA].  
2Q1B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HG:'>HG</scene>, <scene name='pdbligand=BEZ:'>BEZ</scene> and <scene name='pdbligand=LSA:'>LSA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1B OCA].  


==Reference==
==Reference==
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[[Category: twisted beta-sheet]]
[[Category: twisted beta-sheet]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:28:49 2007''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:57:20 2008''

Revision as of 10:57, 23 January 2008

File:2q1b.jpg


2q1b, resolution 1.70Å

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Carbonic Anhydrase II in Complex with Saccharin

About this Structure

2Q1B is a Single protein structure of sequence from Homo sapiens with ZN, HG, BEZ and LSA as ligands. Active as Carbonate dehydratase, with EC number 4.2.1.1 Full crystallographic information is available from OCA.

Reference

Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste., Kohler K, Hillebrecht A, Schulze Wischeler J, Innocenti A, Heine A, Supuran CT, Klebe G, Angew Chem Int Ed Engl. 2007;46(40):7697-9. PMID:17705204

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