2hzs: Difference between revisions

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[[Image:2hzs.~~gif~~|left|200px]]

[[Image:2hzs.png|left|200px]]

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~~'''~~Structure of the Mediator head submodule Med8C/18/20~~'''~~

===Structure of the Mediator head submodule Med8C/18/20===

~~==Overview==~~

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The ~~Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here we show that~~ the ~~head subunits Med8, Med18 and Med20 form a subcomplex~~ (~~Med8~~/18/~~20) with two submodules~~. ~~The highly conserved N-terminal domain of Med8 forms one submodule that binds the TATA box-binding protein (TBP) in vitro and is essential in vivo~~. ~~The second submodule consists of the C-terminal region of Med8 (Med8C~~), ~~Med18 and Med20. X-ray analysis of this submodule reveals that Med18 and Med20 form related beta-barrel folds. A conserved putative protein-interaction face on~~ the ~~Med8C/18/20 submodule includes sites altered by srb mutations, which counteract defects resulting from Pol II truncation~~. ~~Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation~~-~~complex formation and suggest that the Mediator head contains a multipartite TBP~~-~~binding site that can be modulated by transcriptional activators.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16964259}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16964259 is the PubMed ID number.

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==About this Structure==

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[[Category: Channel]]

[[Category: Helix]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:54:39 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:55:58 2008''

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-[[Image:2hzs.gif|left|200px]]
+{{Seed}}
+[[Image:2hzs.png|left|200px]]
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 {{STRUCTURE_2hzs|  PDB=2hzs  |  SCENE=  }}
-'''Structure of the Mediator head submodule Med8C/18/20'''
+===Structure of the Mediator head submodule Med8C/18/20===
-==Overview==
+<!--
-The Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here we show that the head subunits Med8, Med18 and Med20 form a subcomplex (Med8/18/20) with two submodules. The highly conserved N-terminal domain of Med8 forms one submodule that binds the TATA box-binding protein (TBP) in vitro and is essential in vivo. The second submodule consists of the C-terminal region of Med8 (Med8C), Med18 and Med20. X-ray analysis of this submodule reveals that Med18 and Med20 form related beta-barrel folds. A conserved putative protein-interaction face on the Med8C/18/20 submodule includes sites altered by srb mutations, which counteract defects resulting from Pol II truncation. Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators.
+The line below this paragraph, {{ABSTRACT_PUBMED_16964259}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16964259 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16964259}}
 ==About this Structure==
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 [[Category: Channel]]
 [[Category: Helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:54:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:55:58 2008''