2i1p: Difference between revisions

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[[Image:2i1p.jpg|left|200px]]
{{Seed}}
[[Image:2i1p.png|left|200px]]


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{{STRUCTURE_2i1p|  PDB=2i1p  |  SCENE=  }}  
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'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin'''
===Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin===




==Overview==
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Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
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{{ABSTRACT_PUBMED_17245526}}


==About this Structure==
==About this Structure==
2I1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].  
2I1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].  


==Reference==
==Reference==
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[[Category: Ligand binding domain]]
[[Category: Ligand binding domain]]
[[Category: Low density lipoprotein receptor]]
[[Category: Low density lipoprotein receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:58:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:31:21 2008''

Revision as of 07:31, 28 July 2008

File:2i1p.png

Template:STRUCTURE 2i1p

Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin

Template:ABSTRACT PUBMED 17245526

About this Structure

2I1P is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526

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