2i28: Difference between revisions

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[[Image:2i28.jpg|left|200px]]
{{Seed}}
[[Image:2i28.png|left|200px]]


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{{STRUCTURE_2i28|  PDB=2i28  |  SCENE=  }}  
{{STRUCTURE_2i28|  PDB=2i28  |  SCENE=  }}  


'''Solution Structure of alpha-Conotoxin BuIA'''
===Solution Structure of alpha-Conotoxin BuIA===




==Overview==
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We have determined a high-resolution three-dimensional structure of alpha-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout alpha-conotoxin BuIA exhibits strong antagonistic activity at alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChR subtypes like some alpha4/7 conotoxins. alpha-Conotoxin BuIA lacks the C-terminal beta-turn present within the second disulfide loop of alpha4/7 conotoxins, having only a "pseudo omega-shaped" molecular topology. Nevertheless, it contains a functionally critical two-turn helix motif, a feature ubiquitously found in alpha4/7 conotoxins. Such an aspect seems mainly responsible for similarities in the receptor recognition profile of alpha-conotoxin BuIA to alpha4/7 conotoxins. Structural comparison of alpha-conotoxin BuIA with alpha4/7 conotoxins and alpha4/3 conotoxin ImI suggests that presence of the second helical turn portion of the two-turn helix motif in alpha4/7 and alpha4/4 conotoxins may be important for binding to the alpha3 and/or alpha6 subunit of nAChR.
The line below this paragraph, {{ABSTRACT_PUBMED_16979596}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16979596}}


==About this Structure==
==About this Structure==
2I28 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].  
2I28 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].  


==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:59:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:07:51 2008''
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