2i47: Difference between revisions

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[[Image:2i47.gif|left|200px]]
{{Seed}}
[[Image:2i47.png|left|200px]]


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{{STRUCTURE_2i47|  PDB=2i47  |  SCENE=  }}  
{{STRUCTURE_2i47|  PDB=2i47  |  SCENE=  }}  


'''Crystal structure of catalytic domain of TACE with inhibitor'''
===Crystal structure of catalytic domain of TACE with inhibitor===




==Overview==
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By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
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{{ABSTRACT_PUBMED_17064892}}


==About this Structure==
==About this Structure==
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[[Category: Tace-inhibitor complex]]
[[Category: Tace-inhibitor complex]]
[[Category: Tace/adam-17]]
[[Category: Tace/adam-17]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:02:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:17:29 2008''