2i6s: Difference between revisions

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[[Image:2i6s.gif|left|200px]]
{{Seed}}
[[Image:2i6s.png|left|200px]]


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{{STRUCTURE_2i6s|  PDB=2i6s  |  SCENE=  }}  
{{STRUCTURE_2i6s|  PDB=2i6s  |  SCENE=  }}  


'''Complement component C2a'''
===Complement component C2a===




==Overview==
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C2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound. Both structures reveal a near-active conformation of the catalytic center of the serine protease domains, while the von Willebrand factor A-type domains display an intermediate activation state of helix alpha7 with an open, activated metal-ion-dependent adhesion site. The open adhesion site likely serves to enhance the affinity for the ligand C4b, similar to "inside-out" signaling in integrins. Surprisingly, the N-terminal residues of C2a are buried in a crevice near helix alpha7, indicative of a structural switch between C2 and C2a. Extended loops on the protease domain possibly envelop the protruding anaphylatoxin domain of the substrate C3. Together with a putative substrate-induced completion of the oxyanion hole, this may contribute to the high substrate specificity of the convertases.
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{{ABSTRACT_PUBMED_17027507}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease domain]]
[[Category: Serine protease domain]]
[[Category: Von willebrand factor-a domain]]
[[Category: Von willebrand factor-a domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:08:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:25:32 2008''

Revision as of 09:25, 29 July 2008

File:2i6s.png

Template:STRUCTURE 2i6s

Complement component C2a

Template:ABSTRACT PUBMED 17027507

About this Structure

2I6S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of complement component C2A: implications for convertase formation and substrate binding., Milder FJ, Raaijmakers HC, Vandeputte MD, Schouten A, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P, Structure. 2006 Oct;14(10):1587-97. PMID:17027507

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