2i7e: Difference between revisions

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[[Image:2i7e.jpg|left|200px]]
{{Seed}}
[[Image:2i7e.png|left|200px]]


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{{STRUCTURE_2i7e|  PDB=2i7e  |  SCENE=  }}  
{{STRUCTURE_2i7e|  PDB=2i7e  |  SCENE=  }}  


'''GAAA tetralooop receptor complex with associated cobalt hexammine.'''
===GAAA tetralooop receptor complex with associated cobalt hexammine.===




==Overview==
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Metal ions are critical for the proper folding of RNA, and the GAAA tetraloop-receptor is necessary for the optimal folding and function of many RNAs. We have used NMR to investigate the role of metal ions in the structure of the tetraloop-receptor in solution. The NMR data indicate native tertiary structure is formed under a wide range of ionic conditions. The lack of conformational adaptation in response to very different ionic conditions argues against a structural role for divalent ions. Nuclear Overhauser effects to cobalt hexammine and paramagnetic relaxation enhancement induced by manganese ions were used to determine the NMR structures of the tetraloop receptor in association with metal ions, providing the first atomic-level view of these interactions in the solution state. Five manganese and two cobalt hexammine ions could be localized to the RNA surface. The locations of the associated metal ions are similar, but not identical to, those of previously determined crystal structures. The sites of association are in general agreement with nonlinear Poisson-Boltzmann calculations of the electrostatic surface, emphasizing the general importance of diffusely associated ions in RNA tertiary structure.
The line below this paragraph, {{ABSTRACT_PUBMED_17119098}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17119098 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17119098}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7E OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7E OCA].  


==Reference==
==Reference==
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[[Category: Gaaa tetraloop]]
[[Category: Gaaa tetraloop]]
[[Category: Rna tertiary structure]]
[[Category: Rna tertiary structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:10:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:16:34 2008''

Revision as of 21:16, 27 July 2008

File:2i7e.png

Template:STRUCTURE 2i7e

GAAA tetralooop receptor complex with associated cobalt hexammine.

Template:ABSTRACT PUBMED 17119098

About this Structure

Full experimental information is available from OCA.

Reference

Role of metal ions in the tetraloop-receptor complex as analyzed by NMR., Davis JH, Foster TR, Tonelli M, Butcher SE, RNA. 2007 Jan;13(1):76-86. Epub 2006 Nov 21. PMID:17119098

Page seeded by OCA on Mon Jul 28 00:16:34 2008

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