2ido: Difference between revisions

Line 1:

[[Image:2ido.~~gif~~|left|200px]]

[[Image:2ido.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Structure of the E. coli Pol III epsilon-Hot proofreading complex~~'''~~

===Structure of the E. coli Pol III epsilon-Hot proofreading complex===

~~==Overview==~~

<!--

The ~~epsilon subunit of Escherichia coli DNA polymerase III possesses 3'-exonucleolytic proofreading activity. Within the Pol III core~~, ~~epsilon is tightly bound between the alpha subunit (DNA polymerase) and subunit. Here~~, ~~we present~~ the ~~crystal structure of epsilon in complex with HOT,~~ the ~~bacteriophage P1-encoded homolog of ,~~ at 2.~~1 A resolution~~. ~~The epsilon-HOT interface~~ is ~~defined by two areas of contact: an interaction of~~ the ~~previously unstructured N terminus of HOT with an edge of the epsilon central beta-sheet as well as interactions between HOT and the catalytically important helix alpha1~~-~~loop~~-helix alpha2 motif of epsilon. This structure provides insight into how HOT and, by implication, may stabilize the epsilon subunit, thus promoting efficient proofreading during chromosomal replication.

The line below this paragraph, {{ABSTRACT_PUBMED_16973612}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16973612 is the PubMed ID number.

-->

==About this Structure==

Line 38:

Line 42:

[[Category: Pol iii]]

[[Category: Polymerase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:22:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:26:12 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2ido.gif|left|200px]]
+{{Seed}}
+[[Image:2ido.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2ido|  PDB=2ido  |  SCENE=  }}
-'''Structure of the E. coli Pol III epsilon-Hot proofreading complex'''
+===Structure of the E. coli Pol III epsilon-Hot proofreading complex===
-==Overview==
+<!--
-The epsilon subunit of Escherichia coli DNA polymerase III possesses 3'-exonucleolytic proofreading activity. Within the Pol III core, epsilon is tightly bound between the alpha subunit (DNA polymerase) and subunit. Here, we present the crystal structure of epsilon in complex with HOT, the bacteriophage P1-encoded homolog of , at 2.1 A resolution. The epsilon-HOT interface is defined by two areas of contact: an interaction of the previously unstructured N terminus of HOT with an edge of the epsilon central beta-sheet as well as interactions between HOT and the catalytically important helix alpha1-loop-helix alpha2 motif of epsilon. This structure provides insight into how HOT and, by implication, may stabilize the epsilon subunit, thus promoting efficient proofreading during chromosomal replication.
+The line below this paragraph, {{ABSTRACT_PUBMED_16973612}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16973612 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16973612}}
 ==About this Structure==
@@ Line 38: / Line 42: @@
 [[Category: Pol iii]]
 [[Category: Polymerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:22:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:26:12 2008''