2ieg: Difference between revisions

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[[Image:2ieg.gif|left|200px]]
{{Seed}}
[[Image:2ieg.png|left|200px]]


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{{STRUCTURE_2ieg|  PDB=2ieg  |  SCENE=  }}  
{{STRUCTURE_2ieg|  PDB=2ieg  |  SCENE=  }}  


'''Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone'''
===Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone===




==Overview==
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A series of substituted 3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors, which have potential as antidiabetic agents, is described. Initial members of the series showed good enzyme inhibitory potency but poor physical properties. Optimisation of the 1-substituent led to 2,3-dihydroxypropyl compounds which showed good in vitro potency and improved physical properties, together with good DMPK profiles and acute in vivo efficacy in a rat model. X-ray crystallographic data are presented, showing an unexpected variety of binding orientations at the dimer interface site.
The line below this paragraph, {{ABSTRACT_PUBMED_17095214}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17095214}}


==About this Structure==
==About this Structure==
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[[Category: Glycogen phosphorylase]]
[[Category: Glycogen phosphorylase]]
[[Category: Glypho]]
[[Category: Glypho]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:24:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:29:26 2008''
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