2iff: Difference between revisions

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[[Image:2iff.gif|left|200px]]
{{Seed}}
[[Image:2iff.png|left|200px]]


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{{STRUCTURE_2iff|  PDB=2iff  |  SCENE=  }}  
{{STRUCTURE_2iff|  PDB=2iff  |  SCENE=  }}  


'''STRUCTURE OF AN ANTIBODY-LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION'''
===STRUCTURE OF AN ANTIBODY-LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION===




==Overview==
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The structure of the complex between the Fab HyHEL-5 and chicken lysozyme revealed a large interface region containing 23 lysozyme and 28 Fab residues. Arg68 of the lysozyme is centrally placed in this interface and theoretical studies together with binding assays of this Fab to different avian lysozymes have previously shown that this arginine residue is an important contributor to the binding. The Arg68--&gt;Lys mutant binds 10(3) times less well to the HyHEL-5 Fab. We have examined the refined crystal structure of the complex of this mutant lysozyme with the Fab. No global changes occur, but there is an introduction of a new water molecule into the interface that mediates the hydrogen bonding interactions between the lysine and residues on the Fab. These data are compared with the effects of similar changes on the inhibition of serine proteases such as trypsin where the energetic effects of this substitution are small.
The line below this paragraph, {{ABSTRACT_PUBMED_7531245}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7531245}}


==About this Structure==
==About this Structure==
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[[Category: Chacko, S.]]
[[Category: Chacko, S.]]
[[Category: Davies, D R.]]
[[Category: Davies, D R.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:26:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:05:21 2008''

Revision as of 05:05, 28 July 2008

File:2iff.png

Template:STRUCTURE 2iff

STRUCTURE OF AN ANTIBODY-LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION

Template:ABSTRACT PUBMED 7531245

About this Structure

2IFF is a Protein complex structure of sequences from Gallus gallus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of an antibody-lysozyme complex unexpected effect of conservative mutation., Chacko S, Silverton E, Kam-Morgan L, Smith-Gill S, Cohen G, Davies D, J Mol Biol. 1995 Jan 20;245(3):261-74. PMID:7531245

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