2r2w: Difference between revisions
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New page: left|200px<br /> <applet load="2r2w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r2w, resolution 2.01Å" /> '''Urokinase plasminog... |
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[[Image:2r2w. | [[Image:2r2w.jpg|left|200px]]<br /><applet load="2r2w" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2r2w" size=" | |||
caption="2r2w, resolution 2.01Å" /> | caption="2r2w, resolution 2.01Å" /> | ||
'''Urokinase plasminogen activator B-chain-GPPE complex'''<br /> | '''Urokinase plasminogen activator B-chain-GPPE complex'''<br /> | ||
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==Overview== | ==Overview== | ||
Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described. | Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described. | ||
==About this Structure== | ==About this Structure== | ||
2R2W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 4PG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http:// | 2R2W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=4PG:'>4PG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2W OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: urokinase]] | [[Category: urokinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:44:56 2008'' | ||
