2ih1: Difference between revisions

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[[Image:2ih1.gif|left|200px]]
{{Seed}}
[[Image:2ih1.png|left|200px]]


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{{STRUCTURE_2ih1|  PDB=2ih1  |  SCENE=  }}  
{{STRUCTURE_2ih1|  PDB=2ih1  |  SCENE=  }}  


'''Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation'''
===Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation===




==Overview==
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Potassium channels are K+-selective protein pores in cell membrane. The selectivity filter is the functional unit that allows K+ channels to distinguish potassium (K+) and sodium (Na+) ions. The filter's structure depends on whether K+ or Na+ ions are bound inside it. We synthesized a K+ channel containing the d-enantiomer of alanine in place of a conserved glycine and found by x-ray crystallography that its filter maintains the K+ (conductive) structure in the presence of Na+ and very low concentrations of K+. This channel conducts Na+ in the absence of K+ but not in the presence of K+. These findings demonstrate that the ability of the channel to adapt its structure differently to K+ and Na+ is a fundamental aspect of ion selectivity, as is the ability of multiple K+ ions to compete effectively with Na+ for the conductive filter.
The line below this paragraph, {{ABSTRACT_PUBMED_17095703}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17095703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17095703}}


==About this Structure==
==About this Structure==
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[[Category: Valiyaveetil, F I.]]
[[Category: Valiyaveetil, F I.]]
[[Category: Ion channel d-amino acid semi-synthetic]]
[[Category: Ion channel d-amino acid semi-synthetic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:29:39 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:30:48 2008''

Revision as of 01:30, 28 July 2008

File:2ih1.png

Template:STRUCTURE 2ih1

Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation

Template:ABSTRACT PUBMED 17095703

About this Structure

2IH1 is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation., Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R, Science. 2006 Nov 10;314(5801):1004-7. PMID:17095703

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