2iho: Difference between revisions

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[[Image:2iho.jpg|left|200px]]
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[[Image:2iho.png|left|200px]]


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{{STRUCTURE_2iho|  PDB=2iho  |  SCENE=  }}  
{{STRUCTURE_2iho|  PDB=2iho  |  SCENE=  }}  


'''Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc'''
===Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc===




==Overview==
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MOA, a lectin from the mushroom Marasmius oreades, is one of the few reagents that specifically agglutinate blood group B erythrocytes. Further, it is the only lectin known to have exclusive specificity for Galalpha(1,3)Gal-containing sugar epitopes, which are antigens that pose a severe barrier to animal-to-human organ transplantation. We describe here the structure of MOA at 2.4 A resolution, in complex with the linear trisaccharide Galalpha(1,3)Galbeta(1,4)GlcNAc. The structure is dimeric, with two distinct domains per protomer: the N-terminal lectin module adopts a ricinB/beta-trefoil fold and contains three putative carbohydrate-binding sites, while the C-terminal domain serves as a dimerization interface. This latter domain, which has an unknown function, reveals a novel fold with intriguing conservation of an active site cleft. A number of indications suggest that MOA may have an enzymatic function in addition to the sugar-binding properties.
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{{ABSTRACT_PUBMED_17442345}}


==About this Structure==
==About this Structure==
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[[Category: Winter, H C.]]
[[Category: Winter, H C.]]
[[Category: Beta-trefoil]]
[[Category: Beta-trefoil]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:31:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:25:09 2008''

Revision as of 09:25, 29 July 2008

File:2iho.png

Template:STRUCTURE 2iho

Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc

Template:ABSTRACT PUBMED 17442345

About this Structure

2IHO is a Single protein structure of sequence from Marasmius oreades. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Marasmius oreades mushroom lectin in complex with a xenotransplantation epitope., Grahn E, Askarieh G, Holmner A, Tateno H, Winter HC, Goldstein IJ, Krengel U, J Mol Biol. 2007 Jun 8;369(3):710-21. Epub 2007 Mar 15. PMID:17442345

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