2rjc: Difference between revisions

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[[Image:2rjc.gif|left|200px]]<br />

[[Image:2rjc.gif|left|200px]]<br /><applet load="2rjc" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2rjc" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2rjc, resolution 2.00Å" />

'''Crystal structure of L3MBTL1 protein in complex with MES'''<br />

==Overview==

Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4, peptides dimethylated on Lys20 (H4K20me2) show that only the second of the, three MBT repeats can bind mono- and dimethylated histone peptides. Its, binding pocket has similarities to that of 53BP1 and is able to recognize, the degree of histone lysine methylation. An unexpected mode of, peptide-mediated dimerization suggests a possible mechanism for chromatin, compaction by L3MBTL1.

==About this Structure==

2RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and MES as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].

2RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].

==Reference==

L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, Mackenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Nov 18;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117]

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: zinc-finger]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12~~ 23:37:~~30 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:32:04 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2rjc.gif|left|200px]]<br />
+[[Image:2rjc.gif|left|200px]]<br /><applet load="2rjc" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2rjc" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2rjc, resolution 2.00&Aring;" />
 '''Crystal structure of L3MBTL1 protein in complex with MES'''<br />
+==Overview==
+Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4, peptides dimethylated on Lys20 (H4K20me2) show that only the second of the, three MBT repeats can bind mono- and dimethylated histone peptides. Its, binding pocket has similarities to that of 53BP1 and is able to recognize, the degree of histone lysine methylation. An unexpected mode of, peptide-mediated dimerization suggests a possible mechanism for chromatin, compaction by L3MBTL1.
 ==About this Structure==
-RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and MES as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].
+RJC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJC OCA].
+==Reference==
+L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, Mackenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Nov 18;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 41: / Line 46: @@
 [[Category: zinc-finger]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:37:30 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:32:04 2008''