2iqc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2iqc.gif|left|200px]]
{{Seed}}
[[Image:2iqc.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2iqc|  PDB=2iqc  |  SCENE=  }}  
{{STRUCTURE_2iqc|  PDB=2iqc  |  SCENE=  }}  


'''Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex'''
===Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex===




==Overview==
<!--
Fanconi anemia (FA) is a rare autosomal recessive and X-linked chromosomal instability disorder. At least eight FA proteins (FANCA, B, C, E, F, G, L, and M) form a nuclear core complex required for monoubiquitination of a downstream protein, FANCD2. The human FANCF protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E. Our x-ray crystallographic studies of the C-terminal domain of FANCF reveal a helical repeat structure similar to the Cand1 regulator of the Cul1-Rbx1-Skp1-Fbox(Skp2) ubiquitin ligase complex. Two C-terminal loops of FANCF are essential for monoubiquitination of FANCD2 and normal cellular resistance to the DNA cross-linking agent mitomycin C. FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex, indicating that this surface is critical for the proper assembly of the FA core complex.
The line below this paragraph, {{ABSTRACT_PUBMED_17082180}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17082180 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17082180}}


==Disease==
==Disease==
Line 35: Line 39:
[[Category: Fanconi]]
[[Category: Fanconi]]
[[Category: Heat-like repeat]]
[[Category: Heat-like repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:46:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:10:53 2008''

Revision as of 21:10, 28 July 2008

File:2iqc.png

Template:STRUCTURE 2iqc

Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex

Template:ABSTRACT PUBMED 17082180

Disease

Known disease associated with this structure: Fanconi anemia, complementation group F OMIM:[603467]

About this Structure

2IQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex., Kowal P, Gurtan AM, Stuckert P, D'Andrea AD, Ellenberger T, J Biol Chem. 2007 Jan 19;282(3):2047-55. Epub 2006 Nov 1. PMID:17082180

Page seeded by OCA on Tue Jul 29 00:10:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2iqc&oldid=720155"