2is0: Difference between revisions

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-[[Image:2is0.gif|left|200px]]
+{{Seed}}
+[[Image:2is0.png|left|200px]]
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 {{STRUCTURE_2is0|  PDB=2is0  |  SCENE=  }}
-'''Crystal structure of human Beta-secretase complexed with inhibitor'''
+===Crystal structure of human Beta-secretase complexed with inhibitor===
-==Overview==
+<!--
-We describe the discovery and optimization of tertiary carbinamine derived inhibitors of the enzyme beta-secretase (BACE-1). These novel non-transition-state-derived ligands incorporate a single primary amine to interact with the catalytic aspartates of the target enzyme. Optimization of this series provided inhibitors with intrinsic and functional potency comparable to evolved transition state isostere derived inhibitors of BACE-1.
+The line below this paragraph, {{ABSTRACT_PUBMED_17149856}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17149856 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17149856}}
 ==About this Structure==
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 [[Category: Aspartyl protease]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:47:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:42:27 2008''

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