2iu1: Difference between revisions

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[[Image:2iu1.gif|left|200px]]
{{Seed}}
[[Image:2iu1.png|left|200px]]


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{{STRUCTURE_2iu1|  PDB=2iu1  |  SCENE=  }}  
{{STRUCTURE_2iu1|  PDB=2iu1  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN'''
===CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN===




==Overview==
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The carboxy-terminal domain (CTD) of eukaryotic initiation factor 5 (eIF5) plays a central role in the formation of the multifactor complex (MFC), an important intermediate for the 43 S pre-initiation complex assembly. The IF5-CTD interacts directly with the translation initiation factors eIF1, eIF2-beta, and eIF3c, thus forming together with eIF2 bound Met-tRNA(i)(Met) the MFC. In this work we present the high resolution crystal structure of eIF5-CTD. This domain of the protein is exclusively composed out of alpha-helices and is homologous to the carboxy-terminal domain of eIF2B-epsilon (eIF2Bepsilon-CTD). The most striking difference in the two structures is an additional carboxy-terminal helix in eIF5. The binding sites of eIF2-beta, eIF3 and eIF1 were mapped onto the structure. eIF2-beta and eIF3 bind to non-overlapping patches of negative and positive electrostatic potential, respectively.
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{{ABSTRACT_PUBMED_16781736}}


==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Translation inititation]]
[[Category: Translation inititation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:52:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:28:39 2008''

Revision as of 00:28, 28 July 2008

File:2iu1.png

Template:STRUCTURE 2iu1

CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 16781736

About this Structure

2IU1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5., Bieniossek C, Schutz P, Bumann M, Limacher A, Uson I, Baumann U, J Mol Biol. 2006 Jul 7;360(2):457-65. Epub 2006 May 24. PMID:16781736

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