2iuu: Difference between revisions

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[[Image:2iuu.gif|left|200px]]
{{Seed}}
[[Image:2iuu.png|left|200px]]


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{{STRUCTURE_2iuu|  PDB=2iuu  |  SCENE=  }}  
{{STRUCTURE_2iuu|  PDB=2iuu  |  SCENE=  }}  


'''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER'''
===P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER===




==Overview==
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FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.
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{{ABSTRACT_PUBMED_16916635}}


==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:54:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:27:55 2008''

Revision as of 18:27, 28 July 2008

File:2iuu.png

Template:STRUCTURE 2iuu

P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER

Template:ABSTRACT PUBMED 16916635

About this Structure

2IUU is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

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