2j34: Difference between revisions

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[[Image:2j34.jpg|left|200px]]
{{Seed}}
[[Image:2j34.png|left|200px]]


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{{STRUCTURE_2j34|  PDB=2j34  |  SCENE=  }}  
{{STRUCTURE_2j34|  PDB=2j34  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''
===CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX===




==Overview==
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Torsional scans of sulfonamide S-C bonds in small model systems of a series of arylsulfonamide factor Xa inhibitors were performed in order to investigate if conformational effects can help to rationalise the observed SAR. Computational results were in good agreement with the experimental data indicating that the sulfonamide conformation plays an important role in determining the activity in this particular series of factor Xa inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_16982192}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16982192 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16982192}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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