2j3w: Difference between revisions

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[[Image:2j3w.jpg|left|200px]]
{{Seed}}
[[Image:2j3w.png|left|200px]]


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{{STRUCTURE_2j3w|  PDB=2j3w  |  SCENE=  }}  
{{STRUCTURE_2j3w|  PDB=2j3w  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.'''
===THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.===




==Overview==
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Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to elucidate the architecture of TRAPP I. The complex is organized through lateral juxtaposition of the subunits into a flat and elongated particle. We have also localized the site of guanine nucleotide exchange activity to a highly conserved surface encompassing several subunits. We propose that TRAPP I attaches to Golgi membranes with its large flat surface containing many highly conserved residues and forms a platform for protein-protein interactions. This study provides the most comprehensive view of a multisubunit vesicle tethering complex to date, based on which a model for the function of this complex, involving Rab1-GTP and long, coiled-coil tethers, is presented.
The line below this paragraph, {{ABSTRACT_PUBMED_17110339}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17110339}}


==About this Structure==
==About this Structure==
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[[Category: Trapp]]
[[Category: Trapp]]
[[Category: Vesicle transport]]
[[Category: Vesicle transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:17:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:42:41 2008''

Revision as of 13:42, 28 July 2008

File:2j3w.png

Template:STRUCTURE 2j3w

THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.

Template:ABSTRACT PUBMED 17110339

About this Structure

2J3W is a Protein complex structure of sequences from Danio rerio and Mus musculus. Full crystallographic information is available from OCA.

Reference

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering., Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M, Cell. 2006 Nov 17;127(4):817-30. PMID:17110339

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