2j7n: Difference between revisions

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~~'''~~STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA~~'''~~

===STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA===

~~==Overview==~~

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~~RNA silencing refers to a group of RNA~~-~~induced gene~~-~~silencing mechanisms that developed early in the eukaryotic lineage~~, ~~probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates~~, it ~~involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA~~. ~~We report the 2~~.~~3-A resolution crystal structure of QDE-1~~, a cRdRP from Neurospora crassa, and find that it forms a relatively compact dimeric molecule, each subunit of which comprises several domains with, at its core, a catalytic apparatus and protein fold strikingly similar to the ~~catalytic core of the DNA~~-dependent RNA polymerases responsible for transcription. This evolutionary link between the two enzyme types suggests that aspects of RNA silencing in some organisms may recapitulate transcription/replication pathways functioning in the ancient RNA-~~based world.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17147473}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17147473 is the PubMed ID number.

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==About this Structure==

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[[Category: Rna-directed rna polymerase]]

[[Category: Rnai response]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 08~~:28:02 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:49:01 2008''

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-[[Image:2j7n.jpg|left|200px]]
+{{Seed}}
+[[Image:2j7n.png|left|200px]]
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 {{STRUCTURE_2j7n|  PDB=2j7n  |  SCENE=  }}
-'''STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA'''
+===STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA===
-==Overview==
+<!--
-RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA. We report the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora crassa, and find that it forms a relatively compact dimeric molecule, each subunit of which comprises several domains with, at its core, a catalytic apparatus and protein fold strikingly similar to the catalytic core of the DNA-dependent RNA polymerases responsible for transcription. This evolutionary link between the two enzyme types suggests that aspects of RNA silencing in some organisms may recapitulate transcription/replication pathways functioning in the ancient RNA-based world.
+The line below this paragraph, {{ABSTRACT_PUBMED_17147473}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17147473 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17147473}}
 ==About this Structure==
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 [[Category: Rna-directed rna polymerase]]
 [[Category: Rnai response]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:28:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:49:01 2008''