2j85: Difference between revisions

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[[Image:2j85.gif|left|200px]]
{{Seed}}
[[Image:2j85.png|left|200px]]


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{{STRUCTURE_2j85|  PDB=2j85  |  SCENE=  }}  
{{STRUCTURE_2j85|  PDB=2j85  |  SCENE=  }}  


'''B116 OF SULFOLOBUS TURRETED ICOSAHEDRAL VIRUS (STIV)'''
===B116 OF SULFOLOBUS TURRETED ICOSAHEDRAL VIRUS (STIV)===




==Overview==
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Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional crenarchaeal viral families. Due to the central importance of this protein family to crenarchaeal viruses, we have undertaken structural and biochemical studies of B116. The structure reveals a previously unobserved fold consisting of a five-stranded beta-sheet flanked on one side by three alpha helices. Two subunits come together to form a homodimer with a 10-stranded mixed beta-sheet, where the topology of the central strands resembles an unclosed beta-barrel. Highly conserved loops rise above the surface of the saddle-shaped protein and suggest an interaction with the major groove of DNA. The predicted B116-DNA interaction is confirmed by electrophoretic mobility shift assays.
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{{ABSTRACT_PUBMED_17336360}}


==About this Structure==
==About this Structure==
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[[Category: Sulfolobus turreted icosahedral virus]]
[[Category: Sulfolobus turreted icosahedral virus]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:49:27 2008''

Revision as of 01:49, 28 July 2008

File:2j85.png

Template:STRUCTURE 2j85

B116 OF SULFOLOBUS TURRETED ICOSAHEDRAL VIRUS (STIV)

Template:ABSTRACT PUBMED 17336360

About this Structure

2J85 is a Single protein structure of sequence from Sulfolobus turreted icosahedral virus. This structure supersedes the now removed PDB entry 2blk. Full crystallographic information is available from OCA.

Reference

A new DNA binding protein highly conserved in diverse crenarchaeal viruses., Larson ET, Eilers BJ, Reiter D, Ortmann AC, Young MJ, Lawrence CM, Virology. 2007 Jul 5;363(2):387-96. Epub 2007 Mar 2. PMID:17336360

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