2j9i: Difference between revisions

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[[Image:2j9i.jpg|left|200px]]
{{Seed}}
[[Image:2j9i.png|left|200px]]


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{{STRUCTURE_2j9i|  PDB=2j9i  |  SCENE=  }}  
{{STRUCTURE_2j9i|  PDB=2j9i  |  SCENE=  }}  


'''LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.'''
===LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.===




==Overview==
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Lengsin is a major protein of the vertebrate eye lens. It belongs to the hitherto purely prokaryotic GS I branch of the glutamine synthetase (GS) superfamily, but has no enzyme activity. Like the taxon-specific crystallins, Lengsin is the result of the recruitment of an ancient enzyme to a noncatalytic role in the vertebrate lens. Cryo-EM and modeling studies of Lengsin show a dodecamer structure with important similarities and differences with prokaryotic GS I structures. GS homology regions of Lengsin are well conserved, but the N-terminal domain shows evidence of dynamic evolutionary changes. Compared with birds and fish, most mammals have an additional exon corresponding to part of the N-terminal domain; however, in human, this is a nonfunctional pseudoexon. Genes related to Lengsin are also present in the sea urchin, suggesting that this branch of the GS I family, supplanted by GS II enzymes in vertebrates, has an ancient role in metazoans.
The line below this paragraph, {{ABSTRACT_PUBMED_17161372}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17161372}}


==About this Structure==
==About this Structure==
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[[Category: Wyatt, K.]]
[[Category: Wyatt, K.]]
[[Category: Ligase]]
[[Category: Ligase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:33:24 2008''
 
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Revision as of 15:32, 27 July 2008

File:2j9i.png

Template:STRUCTURE 2j9i

LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.

Template:ABSTRACT PUBMED 17161372

About this Structure

2J9I is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens., Wyatt K, White HE, Wang L, Bateman OA, Slingsby C, Orlova EV, Wistow G, Structure. 2006 Dec;14(12):1823-34. PMID:17161372

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