3ull: Difference between revisions

Line 1:

[[Image:3ull.gif|left|200px]]<br />

[[Image:3ull.gif|left|200px]]<br /><applet load="3ull" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="3ull" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="3ull, resolution 2.40Å" />

'''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN'''<br />

==Overview==

We solved the crystal structure of the homotetrameric single-stranded DNA, binding (SSB) protein from human mitochondria at a resolution of 2.4 A., The tetramer is formed by two dimers interacting head-to-head and shows D2, symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes, and eukaryotic mitochondria; this is the first report of an atomic, resolution structure of this type of protein. Using biochemical data and, analysis of sequence homologies, we were able to correlate the functional, properties with structure. We propose that ssDNA wraps around the, tetrameric HsmtSSB protein through electropositive channels guided by, flexible loops.

We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.

==About this Structure==

3ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].

3ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].

==Reference==

Line 23:

Line 22:

[[Category: transit peptide]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:49:~~55 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:43 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3ull.gif|left|200px]]<br />
+[[Image:3ull.gif|left|200px]]<br /><applet load="3ull" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="3ull" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="3ull, resolution 2.40&Aring;" />
 '''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN'''<br />
 ==Overview==
-We solved the crystal structure of the homotetrameric single-stranded DNA, binding (SSB) protein from human mitochondria at a resolution of 2.4 A., The tetramer is formed by two dimers interacting head-to-head and shows D2, symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes, and eukaryotic mitochondria; this is the first report of an atomic, resolution structure of this type of protein. Using biochemical data and, analysis of sequence homologies, we were able to correlate the functional, properties with structure. We propose that ssDNA wraps around the, tetrameric HsmtSSB protein through electropositive channels guided by, flexible loops.
+We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.
 ==About this Structure==
-ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].
+ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].
 ==Reference==
@@ Line 23: / Line 22: @@
 [[Category: transit peptide]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:49:55 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:43 2008''