2je0: Difference between revisions

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[[Image:2je0.gif|left|200px]]
{{Seed}}
[[Image:2je0.png|left|200px]]


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{{STRUCTURE_2je0|  PDB=2je0  |  SCENE=  }}  
{{STRUCTURE_2je0|  PDB=2je0  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF PP32'''
===CRYSTAL STRUCTURE OF PP32===




==Overview==
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The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.
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{{ABSTRACT_PUBMED_17567741}}


==About this Structure==
==About this Structure==
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[[Category: Phapi]]
[[Category: Phapi]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:47:18 2008''

Revision as of 19:47, 28 July 2008

File:2je0.png

Template:STRUCTURE 2je0

CRYSTAL STRUCTURE OF PP32

Template:ABSTRACT PUBMED 17567741

About this Structure

2JE0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:17567741

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