2jj3: Difference between revisions

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[[Image:2jj3.~~jpg~~|left|200px]]

[[Image:2jj3.png|left|200px]]

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~~'''~~ESTROGEN RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST~~'''~~

===ESTROGEN RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST===

~~==Overview==~~

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~~Benzopyrans are selective estrogen receptor~~ (~~ER) beta agonists (SERBAs~~), ~~which bind~~ the ~~ER receptor subtypes alpha and beta in opposite orientations~~. ~~We have used structure based drug design to show that this unique phenomena can be exploited via substitution at the 8~~-~~position of the benzopyran A~~-ring to disrupt binding to ERalpha, thus improving ERbeta subtype selectivity. X-ray cocrystal structures with ERalpha and ERbeta are supportive of this approach to improve selectivity in this structural class.

The line below this paragraph, {{ABSTRACT_PUBMED_17662603}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17662603 is the PubMed ID number.

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==About this Structure==

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[[Category: Zinc]]

[[Category: Zinc-finger]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 09~~:00:21 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:14 2008''

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-[[Image:2jj3.jpg|left|200px]]
+{{Seed}}
+[[Image:2jj3.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2jj3|  PDB=2jj3  |  SCENE=  }}
-'''ESTROGEN RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST'''
+===ESTROGEN RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST===
-==Overview==
+<!--
-Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER receptor subtypes alpha and beta in opposite orientations. We have used structure based drug design to show that this unique phenomena can be exploited via substitution at the 8-position of the benzopyran A-ring to disrupt binding to ERalpha, thus improving ERbeta subtype selectivity. X-ray cocrystal structures with ERalpha and ERbeta are supportive of this approach to improve selectivity in this structural class.
+The line below this paragraph, {{ABSTRACT_PUBMED_17662603}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17662603 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17662603}}
 ==About this Structure==
@@ Line 48: / Line 52: @@
 [[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:00:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:14 2008''