2jm6: Difference between revisions

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[[Image:2jm6.~~gif~~|left|200px]]

[[Image:2jm6.png|left|200px]]

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~~'''~~Solution structure of MCL-1 complexed with NOXAB~~'''~~

===Solution structure of MCL-1 complexed with NOXAB===

~~==Overview==~~

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~~Apoptosis is held in check by prosurvival proteins of the Bcl-2 family.~~ The ~~distantly related BH3-only proteins bind to and antagonize them~~, ~~thereby promoting apoptosis. Whereas binding of~~ the ~~BH3-only protein Noxa~~ to ~~prosurvival Mcl-1 induces Mcl-1 degradation by~~ the ~~proteasome~~, ~~binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels~~. ~~We compared the three~~-~~dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C~~-~~terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17389404}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17389404 is the PubMed ID number.

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==About this Structure==

2JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].

2JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].

==Reference==

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[[Category: Helical bundle]]

[[Category: Mcl-1]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:01:16 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:19:56 2008''

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-[[Image:2jm6.gif|left|200px]]
+{{Seed}}
+[[Image:2jm6.png|left|200px]]
 <!--
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 {{STRUCTURE_2jm6|  PDB=2jm6  |  SCENE=  }}
-'''Solution structure of MCL-1 complexed with NOXAB'''
+===Solution structure of MCL-1 complexed with NOXAB===
-==Overview==
+<!--
-Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
+The line below this paragraph, {{ABSTRACT_PUBMED_17389404}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17389404 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17389404}}
 ==About this Structure==
-JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
+JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
 ==Reference==
@@ Line 36: / Line 40: @@
 [[Category: Helical bundle]]
 [[Category: Mcl-1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:01:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:19:56 2008''