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[[Image:2jmm.jpg|left|200px]]
{{Seed}}
[[Image:2jmm.png|left|200px]]


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{{STRUCTURE_2jmm|  PDB=2jmm  |  SCENE=  }}  
{{STRUCTURE_2jmm|  PDB=2jmm  |  SCENE=  }}  


'''NMR solution structure of a minimal transmembrane beta-barrel platform protein'''
===NMR solution structure of a minimal transmembrane beta-barrel platform protein===




==Overview==
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In this study, we were concerned with the structural role of the surface-exposed extracellular loops of the N-terminal transmembrane (TM) domain of OmpA. A variant of the TM domain of outer membrane protein A (OmpA) with all four such loops shortened, which we call the beta-barrel platform (BBP), was successfully refolded. This indicates that the removed parts of the surface-exposed loops indeed do not contain amino acid sequences critical for this membrane protein's refolding in vitro. BBP has the potential to be used as a template beta-barrel membrane protein structure for the development of novel functions, although our results also highlight the potential difficulties that can arise when functionality is being engineered into the loop regions of membrane proteins. We have used solution nuclear magnetic resonance spectroscopy to determine the global fold of BBP+EF, BBP with a metal ion-binding EF-hand inserted in one of the shortened loops. BBP and BBP+EF in dihexanoylphosphatidylcholine micelles are eight-stranded antiparallel beta-barrels, and BBP represents the smallest beta-structured integral membrane protein known to date.
The line below this paragraph, {{ABSTRACT_PUBMED_17260943}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17260943 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17260943}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMM OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMM OCA].  


==Reference==
==Reference==
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[[Category: Walser, R.]]
[[Category: Walser, R.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:02:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:44:52 2008''

Revision as of 04:45, 28 July 2008

File:2jmm.png

Template:STRUCTURE 2jmm

NMR solution structure of a minimal transmembrane beta-barrel platform protein

Template:ABSTRACT PUBMED 17260943

About this Structure

Full experimental information is available from OCA.

Reference

A minimal transmembrane beta-barrel platform protein studied by nuclear magnetic resonance., Johansson MU, Alioth S, Hu K, Walser R, Koebnik R, Pervushin K, Biochemistry. 2007 Feb 6;46(5):1128-40. PMID:17260943

Page seeded by OCA on Mon Jul 28 07:44:52 2008

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