2jwq: Difference between revisions

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[[Image:2jwq.jpg|left|200px]]
{{Seed}}
[[Image:2jwq.png|left|200px]]


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{{STRUCTURE_2jwq|  PDB=2jwq  |  SCENE=  }}  
{{STRUCTURE_2jwq|  PDB=2jwq  |  SCENE=  }}  


'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study'''
===G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study===




==Overview==
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The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
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{{ABSTRACT_PUBMED_17385760}}


==About this Structure==
==About this Structure==
2JWQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].  
2JWQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].  


==Reference==
==Reference==
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[[Category: Quinacridine]]
[[Category: Quinacridine]]
[[Category: Telomerase inhibitor]]
[[Category: Telomerase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:21:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:55 2008''
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