2knt: Difference between revisions

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[[Image:2knt.gif|left|200px]]
{{Seed}}
[[Image:2knt.png|left|200px]]


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{{STRUCTURE_2knt|  PDB=2knt  |  SCENE=  }}  
{{STRUCTURE_2knt|  PDB=2knt  |  SCENE=  }}  


'''THE 1.2 ANGSTROM STRUCTURE OF KUNITZ TYPE DOMAIN C5'''
===THE 1.2 ANGSTROM STRUCTURE OF KUNITZ TYPE DOMAIN C5===




==Overview==
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The recombinant Kunitz-type domain (C5) of human collagen alpha3(VI) chain was previously described at 1.6 A resolution at room temperature. By changing the crystallization conditions and using synchrotron radiation, we are able to record diffraction data to 1.2 A resolution for crystals of the same space group at 291 K. The protein-water-ion model has been refined anisotropically against these new data using the program SHELXL93; the results converged to an R factor of 15.0%, with all data between 7 and 1.2 A. The final electron-density map reveals a clear chain tracing with a few disordered residues and five residues out of 58 that present alternate conformations. The Cys14-Cys38 bond presents the less frequently observed left-hand conformation (chi1 = -60 degrees). The solvent molecules and a phosphate ion are well ordered with an average B of 38 A2. The high-resolution structure reveals the N and C termini which were missing from the 1.6 A structure.
The line below this paragraph, {{ABSTRACT_PUBMED_9761897}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9761897 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9761897}}


==About this Structure==
==About this Structure==
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[[Category: Extracellular matrix]]
[[Category: Extracellular matrix]]
[[Category: Kunitz inhibitor]]
[[Category: Kunitz inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:29:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 16:24:44 2008''

Revision as of 13:24, 5 July 2008

File:2knt.png

Template:STRUCTURE 2knt

THE 1.2 ANGSTROM STRUCTURE OF KUNITZ TYPE DOMAIN C5

Template:ABSTRACT PUBMED 9761897

About this Structure

2KNT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.2 A refinement of the Kunitz-type domain from the alpha3 chain of human type VI collagen., Merigeau K, Arnoux B, Perahia D, Norris K, Norris F, Ducruix A, Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):306-12. PMID:9761897

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