2mcm: Difference between revisions

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[[Image:2mcm.jpg|left|200px]]
{{Seed}}
[[Image:2mcm.png|left|200px]]


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{{STRUCTURE_2mcm|  PDB=2mcm  |  SCENE=  }}  
{{STRUCTURE_2mcm|  PDB=2mcm  |  SCENE=  }}  


'''MACROMOMYCIN'''
===MACROMOMYCIN===




==Overview==
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The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity.
The line below this paragraph, {{ABSTRACT_PUBMED_2771945}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2771945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2771945}}


==About this Structure==
==About this Structure==
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[[Category: Vanroey, P.]]
[[Category: Vanroey, P.]]
[[Category: Apoprotein]]
[[Category: Apoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:32:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:31:42 2008''
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