2mjp: Difference between revisions

Line 1:

[[Image:2mjp.~~gif~~|left|200px]]

[[Image:2mjp.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~STRUCTURE-BASED IDENTIFICATION OF THE BIOCHEMICAL FUNCTION OF A HYPOTHETICAL PROTEIN FROM METHANOCOCCUS JANNASCHII:MJ0226~~'''~~

===STRUCTURE-BASED IDENTIFICATION OF THE BIOCHEMICAL FUNCTION OF A HYPOTHETICAL PROTEIN FROM METHANOCOCCUS JANNASCHII:MJ0226===

~~==Overview==~~

<!--

~~Almost half of~~ the ~~entire set of predicted genomic products from Methanococcus jannaschii are classified as functionally unknown hypothetical proteins. We present a structure-based identification of~~ the ~~biochemical function of a protein with an~~ as ~~yet unknown function from a M. jannaschii gene, Mj0226. The crystal structure of Mj0226 protein determined~~ at 2.~~2 A resolution reveals that the protein is a homodimer and each monomer folds into an elongated alpha/beta structure of a new fold family~~. ~~Comparisons of Mj0226 protein with protein structures in the database~~, ~~however, indicate that one part of the protein~~ is ~~homologous to some of~~ the ~~nucleotide~~-binding proteins. Biochemical analysis shows that Mj0226 protein is a novel nucleotide triphosphatase that can efficiently hydrolyze nonstandard nucleotides such as XTP to XMP or ITP to IMP, but not the standard nucleotides, in the presence of Mg2+ or Mn2+ ions.

The line below this paragraph, {{ABSTRACT_PUBMED_10404228}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10404228 is the PubMed ID number.

-->

==About this Structure==

Line 35:

Line 39:

[[Category: Pyrophosphatase]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:33:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:40:00 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2mjp.gif|left|200px]]
+{{Seed}}
+[[Image:2mjp.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2mjp|  PDB=2mjp  |  SCENE=  }}
-'''STRUCTURE-BASED IDENTIFICATION OF THE BIOCHEMICAL FUNCTION OF A HYPOTHETICAL PROTEIN FROM METHANOCOCCUS JANNASCHII:MJ0226'''
+===STRUCTURE-BASED IDENTIFICATION OF THE BIOCHEMICAL FUNCTION OF A HYPOTHETICAL PROTEIN FROM METHANOCOCCUS JANNASCHII:MJ0226===
-==Overview==
+<!--
-Almost half of the entire set of predicted genomic products from Methanococcus jannaschii are classified as functionally unknown hypothetical proteins. We present a structure-based identification of the biochemical function of a protein with an as yet unknown function from a M. jannaschii gene, Mj0226. The crystal structure of Mj0226 protein determined at 2.2 A resolution reveals that the protein is a homodimer and each monomer folds into an elongated alpha/beta structure of a new fold family. Comparisons of Mj0226 protein with protein structures in the database, however, indicate that one part of the protein is homologous to some of the nucleotide-binding proteins. Biochemical analysis shows that Mj0226 protein is a novel nucleotide triphosphatase that can efficiently hydrolyze nonstandard nucleotides such as XTP to XMP or ITP to IMP, but not the standard nucleotides, in the presence of Mg2+ or Mn2+ ions.
+The line below this paragraph, {{ABSTRACT_PUBMED_10404228}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10404228 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10404228}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Pyrophosphatase]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:33:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:40:00 2008''