2neo: Difference between revisions

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[[Image:2neo.gif|left|200px]]
{{Seed}}
[[Image:2neo.png|left|200px]]


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{{STRUCTURE_2neo|  PDB=2neo  |  SCENE=  }}  
{{STRUCTURE_2neo|  PDB=2neo  |  SCENE=  }}  


'''SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES'''
===SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES===




==Overview==
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Nucleic acid bulges have been implicated in a number of biological processes and are specific cleavage targets for the enediyne antitumor antibiotic neocarzinostatin chromophore in a base-catalyzed, radical-mediated reaction. The solution structure of the complex between an analog of the bulge-specific cleaving species and an oligodeoxynucleotide containing a two-base bulge was elucidated by nuclear magnetic resonance. An unusual binding mode involves major groove recognition by the drug carbohydrate unit and tight fitting of the wedge-shaped drug in the triangular prism pocket formed by the two looped-out bulge bases and the neighboring base pairs. The two drug rings mimic helical DNA bases, complementing the bent DNA structure. The putative abstracting drug radical is 2.2 +/- 0.1 angstroms from the pro-S H5' of the target bulge nucleotide. This structure clarifies the mechanism of bulge recognition and cleavage by a drug and provides insight into the design of bulge-specific nucleic acid binding molecules.
The line below this paragraph, {{ABSTRACT_PUBMED_8658168}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8658168 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8658168}}


==About this Structure==
==About this Structure==
This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1neo 1neo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NEO OCA].  
This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1neo 1neo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NEO OCA].  


==Reference==
==Reference==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Enediyne antibiotics antitumor agent]]
[[Category: Enediyne antibiotics antitumor agent]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:35:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:23:42 2008''

Revision as of 20:23, 27 July 2008

File:2neo.png

Template:STRUCTURE 2neo

SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES

Template:ABSTRACT PUBMED 8658168

About this Structure

This structure supersedes the now removed PDB entry 1neo. Full experimental information is available from OCA.

Reference

Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog., Stassinopoulos A, Ji J, Gao X, Goldberg IH, Science. 1996 Jun 28;272(5270):1943-6. PMID:8658168

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