2nmb: Difference between revisions

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[[Image:2nmb.jpg|left|200px]]
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[[Image:2nmb.png|left|200px]]


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{{STRUCTURE_2nmb|  PDB=2nmb  |  SCENE=  }}  
{{STRUCTURE_2nmb|  PDB=2nmb  |  SCENE=  }}  


'''DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES.'''
===DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES.===




==Overview==
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The phosphotyrosine-binding (PTB) domain of Numb, a protein involved in asymmetric cell division, has recently been shown to bind to the adapter protein Lnx through an LDNPAY sequence, to the Numb-associated kinase (Nak) through a sequence that does not contain an NPXY motif and to GP(p)Y-containing peptides obtained from library screening. We show here that these diverse peptide sequences bind with comparable affinities to the Numb PTB domain at a common binding site on the surface of the protein. The NMR structure of the Numb PTB domain in complex with a GPpY-containing peptide reveals a novel mechanism of binding with the peptide in a helical turn that does not hydrogen bond to the PTB domain beta-sheet. These results suggest that PTB domains can potentially have multiple modes of peptide recognition and provide a structural basis from which the multiple functions of the Numb PTB domain during asymmetric cell division could arise.
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{{ABSTRACT_PUBMED_9846878}}


==About this Structure==
==About this Structure==
2NMB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NMB OCA].  
2NMB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NMB OCA].  


==Reference==
==Reference==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:38:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:28:37 2008''

Revision as of 15:28, 27 July 2008

File:2nmb.png

Template:STRUCTURE 2nmb

DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES.

Template:ABSTRACT PUBMED 9846878

About this Structure

2NMB is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity., Li SC, Zwahlen C, Vincent SJ, McGlade CJ, Kay LE, Pawson T, Forman-Kay JD, Nat Struct Biol. 1998 Dec;5(12):1075-83. PMID:9846878

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