2nmv: Difference between revisions

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[[Image:2nmv.gif|left|200px]]
{{Seed}}
[[Image:2nmv.png|left|200px]]


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{{STRUCTURE_2nmv|  PDB=2nmv  |  SCENE=  }}  
{{STRUCTURE_2nmv|  PDB=2nmv  |  SCENE=  }}  


'''Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA'''
===Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA===




==Overview==
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UvrB is the damage recognition element of the highly conserved UvrABC pathway that functions in the removal of bulky DNA adducts. Pivotal to this is the formation of a damage detection complex that relies on the ability of UvrB to locate and sequester diverse lesions. Whilst structures of UvrB bound to DNA have recently been reported, none address the issue of lesion recognition. Here, we describe the crystal structure of UvrB bound to a pentanucleotide containing a single fluorescein-adducted thymine that reveals a unique mechanism for damage detection entirely dependent on the exclusion of lesions larger than an undamaged nucleotide.
The line below this paragraph, {{ABSTRACT_PUBMED_17097086}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17097086 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17097086}}


==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: T-fluorescein]]
[[Category: T-fluorescein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:38:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:31:06 2008''
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