2nna: Difference between revisions

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[[Image:2nna.jpg|left|200px]]
{{Seed}}
[[Image:2nna.png|left|200px]]


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{{STRUCTURE_2nna|  PDB=2nna  |  SCENE=  }}  
{{STRUCTURE_2nna|  PDB=2nna  |  SCENE=  }}  


'''Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide'''
===Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide===




==Overview==
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The risk of celiac disease is strongly associated with human leukocyte antigen (HLA) DQ2 and to a lesser extent with HLA DQ8. Although the pathogenesis of HLA-DQ2-mediated celiac disease is established, the underlying basis for HLA-DQ8-mediated celiac disease remains unclear. We showed that T helper 1 (Th1) responses in HLA-DQ8-associated celiac pathology were indeed HLA DQ8 restricted and that multiple, mostly deamidated peptides derived from protease-sensitive sites of gliadin were recognized. This pattern of reactivity contrasted with the more absolute deamidation dependence and relative protease resistance of the dominant gliadin peptide in DQ2-mediated disease. We provided a structural basis for the selection of HLA-DQ8-restricted, deamidated gliadin peptides. The data established that the molecular mechanisms underlying HLA-DQ8-mediated celiac disease differed markedly from the HLA-DQ2-mediated form of the disease. Accordingly, nondietary therapeutic interventions in celiac disease might need to be tailored to the genotype of the individual.
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{{ABSTRACT_PUBMED_17629515}}


==About this Structure==
==About this Structure==
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[[Category: Major histocompatibility complex hla-dq8]]
[[Category: Major histocompatibility complex hla-dq8]]
[[Category: Post translational modification]]
[[Category: Post translational modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:39:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:30:15 2008''

Revision as of 11:30, 27 July 2008

File:2nna.png

Template:STRUCTURE 2nna

Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide

Template:ABSTRACT PUBMED 17629515

About this Structure

2NNA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease., Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI, Purcell AW, Dudek NL, van Heel DA, McCluskey J, Rossjohn J, Anderson RP, Immunity. 2007 Jul;27(1):23-34. Epub 2007 Jul 12. PMID:17629515

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