2no3: Difference between revisions

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[[Image:2no3.gif|left|200px]]
{{Seed}}
[[Image:2no3.png|left|200px]]


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{{STRUCTURE_2no3|  PDB=2no3  |  SCENE=  }}  
{{STRUCTURE_2no3|  PDB=2no3  |  SCENE=  }}  


'''Novel 4-anilinopyrimidines as potent JNK1 Inhibitors'''
===Novel 4-anilinopyrimidines as potent JNK1 Inhibitors===




==Overview==
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A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.
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{{ABSTRACT_PUBMED_17107797}}


==About this Structure==
==About this Structure==
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[[Category: Jnk1]]
[[Category: Jnk1]]
[[Category: Jnk1 inhibitor]]
[[Category: Jnk1 inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:41:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:58:24 2008''